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Aphakia

10
Pipeline Programs
7
Companies
24
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
2
8
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Alcon
AlconFORT WORTH, TX
14 programs
8
AcrySof PanOptixPhase 4
Clareon IOLPhase 4
Clareon PanOptix ProPhase 4
Clareon ToricPhase 4
Clareon TruPlusPhase 4
+9 more programs
Active Trials
NCT04542525Completed32Est. Aug 2021
NCT03733730Completed2,449Est. Oct 2022
NCT04528069Completed58Est. Dec 2021
+6 more trials
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
1
enVistaPhase 31 trial
Active Trials
NCT01230060Completed122Est. Aug 2011
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
1
enVistaPhase 3
RxSight
RxSightALISO VIEJO, CA
7 programs
Light Adjustable lensN/A1 trial
Light Adjustable lensN/A1 trial
Light Adjustable lensN/A1 trial
Light Adjustable lensN/A1 trial
Light Adjustable lensN/A1 trial
+2 more programs
Active Trials
NCT03895034Completed66Est. Mar 2020
NCT04177771Terminated34Est. Dec 2021
NCT05202808Completed500Est. Dec 2024
+4 more trials
Hoya Surgical Optics
Hoya Surgical OpticsSingapore - Washington
4 programs
FY-60ADN/A1 trial
HMY Model YA-60BB IOLN/A1 trial
Study IOLN/A1 trial
iSert 251 intraocular lensN/A1 trial
Active Trials
NCT01268540Completed235Est. Jun 2014
NCT00625313Completed617Est. Dec 2008
NCT01544777Completed42Est. Aug 2012
+1 more trials
Ophtec
OphtecNetherlands - Groningen
2 programs
Artisan Aphakia Intraocular LensN/A1 trial
Artisan Aphakia Intraocular LensN/A1 trial
Active Trials
NCT01547442Suspended300Est. Dec 2025
NCT01547429Suspended300Est. Dec 2025
Lenstec
LenstecBarbados - Christ Church
1 program
Softec HP1 Intraocular LensN/A1 trial
Active Trials
NCT03900260Completed87Est. Jul 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Bausch HealthenVista
Alconaccommodating IOL
AlconAcrySof IQ PanOptix IOL Toric
AlconAcrySof single-piece IOL
RxSightLight Adjustable lens
AlconAcrySof IQ PanOptix Presbyopia Correcting IOL
Alconaccommodating IOL
AlconACRYSOF IQ PanOptix Toric Trifocal IOL
AlconACRYSOF® IQ PanOptix® Toric Trifocal IOL
RxSightLight Adjustable lens
RxSightLight Adjustable lens
RxSightLight Delivery Device
LenstecSoftec HP1 Intraocular Lens
AlconACRYSOF IQ RESTOR +3.0 Multifocal Toric IOL
RxSightLight Adjustable lens

Showing 15 of 24 trials with date data

Clinical Trials (24)

Total enrollment: 6,287 patients across 24 trials

One-Piece Hydrophobic Acrylic Intraocular Lens in Subjects Undergoing Cataract Extraction

Start: Oct 2010Est. completion: Aug 2011122 patients
Phase 3Completed
NCT07147192Alconaccommodating IOL

Feasibility Study of an Accommodating IOL Design

Start: Dec 2025Est. completion: Nov 202785 patients
N/ARecruiting
NCT06166901AlconAcrySof IQ PanOptix IOL Toric

Evaluation of Long-term Safety and Performance of PanOptix Trifocal Intraocular Lens (IOL)

Start: Apr 2024Est. completion: Feb 2025211 patients
N/ACompleted
NCT05799950AlconAcrySof single-piece IOL

A Real-World Evidence (RWE) Long-Term Follow-Up Study to Assess Outcomes of Alcon Monofocal Intraocular Lenses

Start: Aug 2023Est. completion: Jun 2025138 patients
N/ACompleted
NCT05202808RxSightLight Adjustable lens

RxSight Light Adjustable Lens and Light Delivery Device New Enrollment Study

Start: Dec 2021Est. completion: Dec 2024500 patients
N/ACompleted
NCT04755231AlconAcrySof IQ PanOptix Presbyopia Correcting IOL

Post-Market Clinical Study of the PanOptix Intraocular Lens (IOL) in a Chinese Population

Start: Apr 2021Est. completion: Mar 2023181 patients
N/ACompleted
NCT04330001Alconaccommodating IOL

Exploratory Clinical Study for Techniques Associated With the Fluid Accommodating IOL

Start: Dec 2020Est. completion: May 202399 patients
N/ACompleted
NCT04542525AlconACRYSOF IQ PanOptix Toric Trifocal IOL

Clinical Investigation of an AcrySof IQ PanOptix Toric Intraocular Lens

Start: Dec 2020Est. completion: Aug 202132 patients
N/ACompleted
NCT04528069AlconACRYSOF® IQ PanOptix® Toric Trifocal IOL

Clinical Investigation of the Visual Outcomes and Safety of a Trifocal Toric IOL in an Asian Population

Start: Nov 2020Est. completion: Dec 202158 patients
N/ACompleted
NCT04529616RxSightLight Adjustable lens

Single Center Exploratory Study To Evaluate The Use Of The RxSight Light Adjustable Lens (LAL) And The Light Delivery Device (LDD) To Improve Visual Outcomes

Start: May 2020Est. completion: Oct 202279 patients
N/ACompleted
NCT04177771RxSightLight Adjustable lens

A Clinical Study to Evaluate The Safety and Effectiveness of The RxSight Light Adjustable Lens (LAL) In Subjects Desiring an Extended Depth of Focus

Start: Nov 2019Est. completion: Dec 202134 patients
N/ATerminated
NCT04005586RxSightLight Delivery Device

A Clinical Study to Evaluate The Safety and Effectiveness of Performing 0.50 Diopter Astigmatism Correction on the Commercially Available RxSight Light Adjustable Lens (LAL)

Start: Jul 2019Est. completion: Mar 202025 patients
N/ACompleted
NCT03900260LenstecSoftec HP1 Intraocular Lens

Clinical Evaluation of the Lenstec Softec HP1 Intraocular Lens

Start: Apr 2019Est. completion: Jul 202187 patients
N/ACompleted
NCT03733730AlconACRYSOF IQ RESTOR +3.0 Multifocal Toric IOL

Post Approval Study of the AcrySof® IQ ReSTOR® Toric IOLs

Start: Nov 2018Est. completion: Oct 20222,449 patients
N/ACompleted
NCT03660865RxSightLight Adjustable lens

Clinical Study to Evaluate the Safety and Effectiveness of the RxSight Light Adjustable Lens (LAL) in Subjects With Prior Corneal Refractive Surgery

Start: Aug 2018Est. completion: Apr 2020105 patients
N/ACompleted
NCT03895034RxSightLight Adjustable lens

Exploratory Study to Evaluate the Use of the RxSight Light Adjustable Lens (LAL) and the Light Delivery Device (LDD) to Improve Visual Outcomes

Start: Jun 2018Est. completion: Mar 202066 patients
N/ACompleted
NCT03729024RxSightLight Adjustable lens

Exploratory Study to Evaluate Uncorrected Distance Vision and Quality of Vision After Light Treatments of an Implanted RxSight Light Adjustable Lens (RXLAL) With The Light Delivery Device (LDD) in Subjects With Preoperative Corneal Astigmatism

Start: Jan 2018Est. completion: Feb 202021 patients
N/ACompleted
NCT03170154Alconmonofocal IOL

Clinical Investigation of the Clareon® Intraocular Lens (IOL)

Start: Jul 2017Est. completion: Feb 2019376 patients
N/ACompleted

Visual Quality Following Aspheric Intraocular Lens (IOL) Implantation - a Comparative Clinical Study

Start: Feb 2012Est. completion: Aug 201242 patients
N/ACompleted
NCT01547442OphtecArtisan Aphakia Intraocular Lens

Artisan Aphakia Lens for the Correction of Aphakia in Children

Start: Jan 2012Est. completion: Dec 2025300 patients
N/ASuspended
NCT01547429OphtecArtisan Aphakia Intraocular Lens

Artisan Aphakia Lens for the Correction of Aphakia (Secondary) in Adults

Start: Jan 2012Est. completion: Dec 2025300 patients
N/ASuspended
NCT01292629Hoya Surgical OpticsiSert 251 intraocular lens

Comparison of the Hoya Surgical Optics (HSO) iSert 251 Posterior Chamber Aspheric Aphakic Intraocular Lens to Historical / Literature Controls.

Start: Feb 2011Est. completion: May 2012125 patients
N/ACompleted

Comparison of Aspheric Toric & Non-toric Aphakic Intraocular Lenses

Start: Dec 2010Est. completion: Jun 2014235 patients
N/ACompleted
NCT00625313Hoya Surgical OpticsHMY Model YA-60BB IOL

Clinical Study of a UV-Absorbing Acrylic Posterior Chamber Intraocular Lens

Start: Mar 2004Est. completion: Dec 2008617 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 6,287 patients
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.