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Anterior Cruciate Ligament Injury

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Pipeline Programs
6
Companies
9
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Human BioSciences
Human BioSciencesWV - Martinsburg
4 programs
Functional Resistance Training with BraceN/A1 trial
Mechanical Perturbation TrainingN/A1 trial
Neuromuscular Electrical StimulationN/A1 trial
Operant ConditioningN/A1 trial
Active Trials
NCT03282565Completed30Est. Dec 2020
NCT03080402Unknown24Est. Dec 2017
NCT03626857Completed135Est. Jan 2025
+1 more trials
Miach Orthopaedics
Miach OrthopaedicsMA - Westborough
2 programs
ACL Repair with MIACH ScaffoldN/A1 trial
Bridge-Enhanced ACL RestorationN/A1 trial
Active Trials
NCT02292004Active Not Recruiting20Est. Dec 2026
NCT03348995Active Not Recruiting250Est. Apr 2034
Zimmer Biomet
Zimmer BiometFL - Jacksonville
1 program
EZ Pass Suture PasserN/A1 trial
Active Trials
NCT03914703Completed73Est. Apr 2024
Simbex
SimbexNH - Lebanon
1 program
Mechanical Perturbation TrainingN/A
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
Muscle Strength TrainingN/A1 trial
Active Trials
NCT07423819Not Yet Recruiting160Est. Nov 2026
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Patient educaiton materials - Print basedN/A1 trial
Active Trials
NCT03372889Completed178Est. Nov 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
UNION therapeuticsMuscle Strength Training
Zimmer BiometEZ Pass Suture Passer
Human BioSciencesNeuromuscular Electrical Stimulation
Miach OrthopaedicsBridge-Enhanced ACL Restoration
Human BioSciencesFunctional Resistance Training with Brace
Human BioSciencesOperant Conditioning
Colorado TherapeuticsPatient educaiton materials - Print based
Human BioSciencesMechanical Perturbation Training
Miach OrthopaedicsACL Repair with MIACH Scaffold

Clinical Trials (9)

Total enrollment: 881 patients across 9 trials

NCT07423819UNION therapeuticsMuscle Strength Training

Sports Rehabilitation Therapy for Knee Joint Sports Injuries: A Case Study of Anterior Cruciate Ligament Injury and Patellar Chondromalacia

Start: Mar 2026Est. completion: Nov 2026160 patients
N/ANot Yet Recruiting
NCT03914703Zimmer BiometEZ Pass Suture Passer

MDR EZ Pass and Precision Flexible Reamer

Start: Aug 2019Est. completion: Apr 202473 patients
N/ACompleted
NCT03626857Human BioSciencesNeuromuscular Electrical Stimulation

MiACLR: Michigan Initiative for Anterior Cruciate Ligament Rehabilitation

Start: Feb 2019Est. completion: Jan 2025135 patients
N/ACompleted
NCT03348995Miach OrthopaedicsBridge-Enhanced ACL Restoration

The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration

Start: Apr 2018Est. completion: Apr 2034250 patients
N/AActive Not Recruiting
NCT03282565Human BioSciencesFunctional Resistance Training with Brace

Functional Resistance Training to Improve Knee Function After ACL Reconstruction

Start: Mar 2018Est. completion: Dec 202030 patients
N/ACompleted
NCT03209531Human BioSciencesOperant Conditioning

Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

Start: Sep 2017Est. completion: Nov 202511 patients
N/ACompleted
NCT03372889Colorado TherapeuticsPatient educaiton materials - Print based

On-Q Catheter Caregiver Education

Start: Jul 2017Est. completion: Nov 2020178 patients
N/ACompleted
NCT03080402Human BioSciencesMechanical Perturbation Training

Mechanical Perturbation Training for ACL Injury Prevention

Start: Feb 2017Est. completion: Dec 201724 patients
N/AUnknown
NCT02292004Miach OrthopaedicsACL Repair with MIACH Scaffold

Bridge-Enhanced ACL Repair-Safety Study (BEAR Trial)

Start: Jan 2015Est. completion: Dec 202620 patients
N/AActive Not Recruiting

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

6 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.