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Anterior Cruciate Ligament Injuries

1
Pipeline Programs
7
Companies
8
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
1
Anakinra injectionPhase 11 trial
Active Trials
NCT03968913Recruiting32Est. Jan 2027
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
ACL ReconstructionN/A1 trial
Werewolf FLOW 50N/A1 trial
Active Trials
NCT04039971Active Not Recruiting150Est. Aug 2029
NCT04998656Completed182Est. Nov 2024
Xiros
XirosUK - Leeds
1 program
JewelACLN/A1 trial
Active Trials
NCT04580290Completed120Est. Apr 2021
Enterprise Therapeutics
1 program
KneeStimN/A1 trial
Active Trials
NCT06341868Recruiting60Est. Sep 2026
Medacta
MedactaSwitzerland - Castel San Pietro
1 program
Mectascrew-CN/A1 trial
Active Trials
NCT05791656Unknown44Est. Mar 2025
Linnaeus Therapeutics
Linnaeus TherapeuticsNJ - Haddonfield
1 program
Operation KorsbandN/A1 trial
Active Trials
NCT05752695Enrolling By Invitation200Est. Dec 2028
Miach Orthopaedics
Miach OrthopaedicsMA - Westborough
1 program
The BEAR® ImplantN/A1 trial
Active Trials
NCT05398341Active Not Recruiting300Est. Jan 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Angeles TherapeuticsAnakinra injection
Enterprise TherapeuticsKneeStim
Linnaeus TherapeuticsOperation Korsband
MedactaMectascrew-C
Miach OrthopaedicsThe BEAR® Implant
Colorado TherapeuticsWerewolf FLOW 50
XirosJewelACL
Colorado TherapeuticsACL Reconstruction

Clinical Trials (8)

Total enrollment: 1,088 patients across 8 trials

NCT03968913Angeles TherapeuticsAnakinra injection

Biologic Therapy to Prevent Osteoarthritis After ACL Injury

Start: Sep 2021Est. completion: Jan 202732 patients
Phase 1Recruiting
NCT06341868Enterprise TherapeuticsKneeStim

Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets

Start: Sep 2024Est. completion: Sep 202660 patients
N/ARecruiting
NCT05752695Linnaeus TherapeuticsOperation Korsband

Operation Korsband

Start: Sep 2023Est. completion: Dec 2028200 patients
N/AEnrolling By Invitation
NCT05791656MedactaMectascrew-C

Interference Screw Mectascrew-C Postmarket Study

Start: Mar 2023Est. completion: Mar 202544 patients
N/AUnknown
NCT05398341Miach OrthopaedicsThe BEAR® Implant

A Prospective Cohort Post Market Registry Evaluating Outcomes of Bridge-Enhanced ACL Restoration (BEAR®)

Start: Feb 2023Est. completion: Jan 2027300 patients
N/AActive Not Recruiting
NCT04998656Colorado TherapeuticsWerewolf FLOW 50

Werewolf Flow 50 During ACL Reconstruction

Start: Jul 2021Est. completion: Nov 2024182 patients
N/ACompleted
NCT04580290XirosJewelACL

Jewel ACL Post Market Clinical Follow Up Study

Start: Oct 2020Est. completion: Apr 2021120 patients
N/ACompleted
NCT04039971Colorado TherapeuticsACL Reconstruction

Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial

Start: Aug 2020Est. completion: Aug 2029150 patients
N/AActive Not Recruiting

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 1,088 patients
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.