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Ankle Sprain

5
Pipeline Programs
4
Companies
6
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
1
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
3 programs
1
1
1
diclofenac potassium 25 mg tabletPhase 41 trial
Diclofenac sodium topical gel 1%Phase 31 trial
Diclofenac diethylamine 2.32% gelPhase 21 trial
Active Trials
NCT00573768Completed271Est. Jul 2008
NCT01255423Completed206Est. Jun 2011
NCT01666197Completed100Est. Jan 2013
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
IndomethacinPhase 41 trial
Active Trials
NCT01957215Completed270Est. Sep 2014
Teikoku Seiyaku
Teikoku SeiyakuJapan - Higashikagawa
1 program
1
Esflurbiprofen Hydrogel PatchPhase 21 trial
Active Trials
NCT02729207Terminated6Est. Dec 2016
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Semiconductor Embedded SockN/A1 trial
Active Trials
NCT07025733Recruiting100Est. Dec 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
ViiV HealthcareIndomethacin
Sandozdiclofenac potassium 25 mg tablet
SandozDiclofenac sodium topical gel 1%
Teikoku SeiyakuEsflurbiprofen Hydrogel Patch
SandozDiclofenac diethylamine 2.32% gel
Colorado TherapeuticsSemiconductor Embedded Sock

Clinical Trials (6)

Total enrollment: 953 patients across 6 trials

NCT01957215ViiV HealthcareIndomethacin

Efficacy of Topical Indomethacin Patch Over Placebo in Ankle Sprain Pain Relief

Start: Oct 2013Est. completion: Sep 2014270 patients
Phase 4Completed
NCT01666197Sandozdiclofenac potassium 25 mg tablet

Efficacy and Safety of Diclofenac Potassium 25 mg Tablet Taken Three Times Daily in Subjects With Acute Joint Pain

Start: Aug 2012Est. completion: Jan 2013100 patients
Phase 4Completed
NCT01255423SandozDiclofenac sodium topical gel 1%

Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied 4 Times Daily in Subjects With Acute Ankle Sprain

Start: Nov 2010Est. completion: Jun 2011206 patients
Phase 3Completed
NCT02729207Teikoku SeiyakuEsflurbiprofen Hydrogel Patch

Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain

Start: Jul 2016Est. completion: Dec 20166 patients
Phase 2Terminated
NCT00573768SandozDiclofenac diethylamine 2.32% gel

Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel in Patients With Acute Ankle Sprain

Start: Nov 2007Est. completion: Jul 2008271 patients
Phase 2Completed
NCT07025733Colorado TherapeuticsSemiconductor Embedded Sock

Semiconductor Embedded Socks for Ankle Sprains

Start: Apr 2025Est. completion: Dec 2027100 patients
N/ARecruiting

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 953 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.