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Anesthesia, General

37
Pipeline Programs
9
Companies
25
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
12
0
24
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
1 program
1
SedlinePhase 41 trial
Active Trials
NCT00938782Completed67Est. Jun 2012
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
18 programs
6
12
RocuroniumPhase 31 trial
SugammadexPhase 31 trial
SugammadexPhase 31 trial
SugammadexPhase 31 trial
SugammadexPhase 31 trial
+13 more programs
Active Trials
NCT00591786Completed100Est. Oct 2006
NCT00535743Completed174Est. Jul 2004
NCT00552929Completed102Est. Sep 2006
+15 more trials
MSD
MSDIreland - Ballydine
18 programs
6
12
RocuroniumPhase 3
SugammadexPhase 3
SugammadexPhase 3
SugammadexPhase 3
SugammadexPhase 3
+13 more programs
Abbott
AbbottABBOTT PARK, IL
2 programs
Clinical Practice of Inhalation Anesthesia With Sevoflurane in ChinaN/A1 trial
Estimate the Behavior of Chinese Anesthesiologists Practicing General Anesthesia With SevofluraneN/A1 trial
Active Trials
NCT01715857Completed4,100Est. Jul 2013
NCT01199471Completed4,000Est. Nov 2010
Medtronic
MedtronicNJ - Phillipsburg
1 program
BIS deviceN/A1 trial
Active Trials
NCT03553953Completed98Est. Aug 2020
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
Clinical Practice of Inhalation Anesthesia With Sevoflurane in ChinaN/A
GE HealthCare
1 program
Monitoring of frontal electrical muscle activityN/A1 trial
Active Trials
NCT03366662Withdrawn0Est. Dec 2018
Medasense Biometrics
Medasense BiometricsIsrael - Ramat Gan
1 program
PMD-200N/A1 trial
Active Trials
NCT03452163Terminated3Est. Nov 2019
Stryker
StrykerCA - San Jose
1 program
SNAP monitor; Bispectral Index MonitorN/A1 trial
Active Trials
NCT00829803Completed40Est. Jan 2011

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
PfizerSedline
Sharp TherapeuticsSugammadex
Sharp TherapeuticsSugammadex
Sharp TherapeuticsRocuronium
Sharp TherapeuticsSugammadex
Sharp TherapeuticsSugammadex
Sharp TherapeuticsSugammadex
Sharp Therapeuticssugammadex
Sharp TherapeuticsSugammadex
Sharp TherapeuticsSugammadex
Sharp TherapeuticsSugammadex
Sharp TherapeuticsSugammadex
Sharp TherapeuticsSugammadex
Sharp Therapeuticssugammadex
Sharp TherapeuticsSugammadex

Showing 15 of 25 trials with date data

Clinical Trials (25)

Total enrollment: 10,674 patients across 25 trials

Using the SEDLine for the Titration of Sevoflurane in Elderly Patients Recovery Using the SEDLine TM for the Titration of Sevoflurane in Elderly Patients Undergoing Non-Cardiac Surgery After Beta-Adrenergic Blockade

Start: Jul 2006Est. completion: Jun 201267 patients
Phase 4Completed

Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)

Start: Jan 2010Est. completion: Sep 2010308 patients
Phase 3Completed

Efficacy and Safety of 4.0 mg/kg Sugammadex at 1-2 PTC in Chinese and European Subjects (Study 19.4.335)(P05775AM1)(COMPLETED)

Start: Jan 2010Est. completion: Aug 2010164 patients
Phase 3Completed

Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)

Start: Jul 2008Est. completion: May 2009140 patients
Phase 3Completed

Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028)

Start: Dec 2006Est. completion: Mar 200752 patients
Phase 3Completed

Comparison of Recovery From Rocuronium 1.2 mg/kg Followed by Sugammadex (Org 25969) 16 mg/kg at 3 Minutes With Recovery From Succinylcholine 1.0 mg/kg (19.4.303)(P05946)(MK-8616-026)

Start: Feb 2006Est. completion: Sep 2006115 patients
Phase 3Completed

Comparison of the Efficacy, Safety, and Pharmacokinetics of Sugammadex (MK-8616; Org 25969) in Elderly Participants With Adult Participants (MK-8616-029)

Start: Dec 2005Est. completion: Oct 2006162 patients
Phase 3Completed

Comparison of Sugammadex (MK-8616/Org 25969) With Neostigmine Administered at 1-2 Post-tetanic Counts (PTCs) After Administration of Rocuronium or Vecuronium (19.4.302/P05945/MK-8616-025)

Start: Nov 2005Est. completion: Jan 2007182 patients
Phase 3Completed

Comparison of Sugammadex (Org 25969) With Neostigmine as Reversal Agents for Rocuronium or Vecuronium at Reappearance of T2 (P05960)

Start: Nov 2005Est. completion: Mar 2006198 patients
Phase 3Completed

Comparison of Rocuronium and Org 25969 With Cisatracurium and Neostigmine (19.4.310)(P05931)

Start: Nov 2005Est. completion: Aug 200684 patients
Phase 3Completed

Safety and Efficacy of Sugammadex (Org 25969, MK-8616) in Participants With or Having a Past History of Pulmonary Disease (19.4.308) (P05932) (MK-8616-017)

Start: Oct 2005Est. completion: Sep 200686 patients
Phase 3Completed

Use of Sugammadex at the End of Case in Routine Anesthesia (MK-8616-023)

Start: Oct 2005Est. completion: May 2006224 patients
Phase 3Completed

Efficacy, Pharmacokinetics and Safety of Org 25969 in Subjects With Normal or Impaired Renal Function (19.4.304)(P05948)(COMPLETED)

Start: Jun 2005Est. completion: Apr 200630 patients
Phase 3Completed

A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part A: Japanese Participants (P05956)

Start: Jan 2006Est. completion: Dec 2006100 patients
Phase 2Completed

A Bridging Trial Comparing Sugammadex (Org 25969) at 1-2 Post-Tetanic Count (PTC) in Japanese Participants. Part A (P05957)

Start: Dec 2005Est. completion: Oct 2006100 patients
Phase 2Completed

A Bridging Trial Comparing Sugammadex (Org 25969) at 1-2 Post-Tetanic Count (PTC) in Caucasian Participants. Part B (P05974)

Start: Oct 2005Est. completion: Sep 2006102 patients
Phase 2Completed

A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part B: Caucasian Participants (P05971)

Start: Sep 2005Est. completion: Aug 2006100 patients
Phase 2Completed

Dose-Finding Trial With Sugammadex Administered at 3 and 15 Minutes After 1.0 and 1.2 mg/kg Rocuronium Bromide in Participants of ASA Class 1-3 (P05944; MK-8616-024)

Start: Mar 2004Est. completion: Jul 2004174 patients
Phase 2Completed

Use of Sugammadex Administered at 5 Minutes After Administration of 1.2 mg/kg Esmeron® (19.4.205)(P05942)

Start: Nov 2003Est. completion: Jul 200445 patients
Phase 2Completed

Characterization of Artifacts in the BIS™ EEG Signals in General Anesthesia Patients in Operating Room

Start: Aug 2018Est. completion: Aug 202098 patients
N/ACompleted

Performance Assessment of the PMD-200 in Subjects at Neurointensive Care Unit

Start: Mar 2018Est. completion: Nov 20193 patients
N/ATerminated
NCT03366662GE HealthCareMonitoring of frontal electrical muscle activity

The Effect of Frontal Electromyogram (F-EMG) Activity on the Entropy Index Behavior During General Anesthesia

Start: Dec 2017Est. completion: Dec 20180
N/AWithdrawn
NCT01715857AbbottClinical Practice of Inhalation Anesthesia With Sevoflurane in China

Clinical Practice of Inhalation Anesthesia With Sevoflurane in China

Start: Jul 2012Est. completion: Jul 20134,100 patients
N/ACompleted
NCT01199471AbbottEstimate the Behavior of Chinese Anesthesiologists Practicing General Anesthesia With Sevoflurane

Estimate the Behavior of Chinese Anesthesiologists Practicing General Anesthesia With Sevoflurane

Start: Sep 2010Est. completion: Nov 20104,000 patients
N/ACompleted
NCT00829803StrykerSNAP monitor; Bispectral Index Monitor

A Study to Assess Indices of SNAP vs VISTA on Surgical Patients Undergoing General Anesthesia

Start: Feb 2009Est. completion: Jan 201140 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

24 late-stage (Phase 3) programs, potential near-term approvals
9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.