Amyloidosis, Hereditary

2
Pipeline Programs
2
Companies
2
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

RNA Therapeutic
2100%

On Market (1)

Approved therapies currently available

Alnylam Pharmaceuticals
ONPATTROApproved
patisiran
Alnylam Pharmaceuticals
intravenous2018

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Alnylam Pharmaceuticals
1 program
1
1
PatisiranPhase 3RNA Therapeutic1 trial
Active Trials
NCT03759379Completed164Est. Nov 2025
Ionis Pharmaceuticals
1 program
InotersenN/ARNA Therapeutic1 trial
Active Trials
NCT03400098Approved For Marketing

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Alnylam PharmaceuticalsPatisiran

Clinical Trials (2)

Total enrollment: 164 patients across 2 trials

HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

Start: Feb 2019Est. completion: Nov 2025164 patients
Phase 3Completed

ATTR Expanded Access Program (EAP) by Ionis

N/AApproved For Marketing

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
2 companies competing in this space