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Allogeneic Hematopoietic Stem Cell Transplantation

1
Pipeline Programs
3
Companies
50
Clinical Trials
8 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 2 programs with unclassified modality

On Market (1)

Approved therapies currently available

Takeda
ENTYVIOApproved
vedolizumab
Takeda
Integrin Receptor Antagonist [EPC]injection2014
100M Part D

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Takeda
TakedaTOKYO, Japan
1 program
1
ENTYVIO(Vedolizumab)PHASE_2Monoclonal Antibody5 trials
Active Trials
NCT06856135Available
NCT07123350Active Not Recruiting120Est. Mar 2026
NCT07240168Active Not Recruiting400Est. Aug 2026
+2 more trials
Eppendorf
EppendorfGermany - Hamburg
1 program
Humor therapyN/A1 trial
Active Trials
NCT03593161Unknown126Est. Sep 2019
Seres Therapeutics
Seres TherapeuticsCAMBRIDGE, MA
1 program
Vancomycin Pre-TreatmentPHASE_11 trial
Active Trials
NCT04995653Completed60Est. Jul 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab
TakedaVedolizumab

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 10,503 patients across 50 trials

A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

Start: Mar 2025Est. completion: Jun 2028400 patients
Phase 4Recruiting

Comparison of Vedolizumab Treatment to Adalimumab Dose Intensification in Crohn's Disease Patients With Loss of Response or Biomarker Activity to Adalimumab on First Line With Therapeutic Drug Concentration.

Start: Oct 2024Est. completion: Jan 2027220 patients
Phase 4Recruiting

VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease

Start: Aug 2024Est. completion: Feb 2029304 patients
Phase 4Recruiting

A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

Start: Jun 2024Est. completion: Jul 202765 patients
Phase 4Recruiting

A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease

Start: Apr 2024Est. completion: Jun 2027100 patients
Phase 4Recruiting

A Study of Vedolizumab in People With Ulcerative Colitis and Crohn's Disease

Start: Dec 2021Est. completion: Feb 2024150 patients
Phase 4Completed

Investigation of the Faecal Loss of Vedolizumab and Its Role in Influencing Serum Drug Levels, Outcomes and Response in Ulcerative Colitis

Start: Jul 2019Est. completion: Mar 202030 patients
Phase 4Unknown

Postmarketing Vedolizumab Milk-Only Lactation Study in Lactating Women With Active Ulcerative Colitis or Crohn's Disease

Start: Nov 2017Est. completion: Feb 201911 patients
Phase 4Completed

An Open Label Single-arm Phase 4 Study of Vedolizumab in Subjects With Newly Diagnosed Active Ulcerative Colitis

Start: Jul 2017Est. completion: Feb 20190
Phase 4Withdrawn

Triple Combination Therapy in High Risk Crohn's Disease (CD)

Start: Apr 2017Est. completion: Jul 202255 patients
Phase 4Completed

Vedolizumab Intravenous (IV) Dose Optimization in Ulcerative Colitis

Start: Mar 2017Est. completion: Oct 2020278 patients
Phase 4Completed

Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study

Start: Nov 2016Est. completion: Aug 20200
Phase 4Withdrawn

Extended Access Program of Vedolizumab IV in Ulcerative Colitis and Crohn's Disease

Start: Aug 2016Est. completion: Jan 2023331 patients
Phase 4Terminated

Value of Pharmacokinetic Assays in the Prediction of Induction and Maintenance Therapeutic Response in Crohn's Disease

Start: Jul 2016Est. completion: Jan 202347 patients
Phase 4Terminated

A Study to Evaluate Efficacy, of Early Versus Late Use of Vedolizumab in Crohn's Disease: the LOVE-CD Study

Start: Jul 2015Est. completion: May 2023260 patients
Phase 4Completed

A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

Start: Jan 2025Est. completion: Jun 202770 patients
Phase 3Recruiting

A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis

Start: Nov 2024Est. completion: Dec 202930 patients
Phase 3Recruiting

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

Start: Feb 2022Est. completion: May 2026120 patients
Phase 3Recruiting

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Ulcerative Colitis (UC)

Start: Oct 2021Est. completion: Jul 2025121 patients
Phase 3Completed

A Study of Intravenous Vedolizumab Administered Every 4 Weeks in Japanese Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease

Start: Jun 2021Est. completion: Nov 202757 patients
Phase 3Active Not Recruiting

A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease

Start: Apr 2016Est. completion: Jun 2024746 patients
Phase 3Completed

Effect of Intravenous (IV) Vedolizumab on Mucosal Healing in Crohn's Disease

Start: Mar 2015Est. completion: Feb 2018101 patients
Phase 3Completed

An Open-label Study of Vedolizumab (MLN0002) in Participants With Ulcerative Colitis and Crohn's Disease

Start: May 2009Est. completion: Oct 20172,243 patients
Phase 3Completed

Vedolizumab for the Treatment of Collagenous Gastritis

Start: Dec 2024Est. completion: Oct 202611 patients
Phase 2Active Not Recruiting

Long-term Safety With Vedolizumab Intravenous (IV) in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Start: Jul 2018Est. completion: Jul 202559 patients
Phase 2Completed

Vedolizumab Induction May Prevent Celiac Enteritis

Start: Jun 2018Est. completion: Oct 20181 patients
Phase 2Terminated

Vedolizumab IV in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Start: Nov 2017Est. completion: May 202089 patients
Phase 2Completed

A Dose-Finding Study of Vedolizumab for Treatment of Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease (GvHD) in Participants Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT)

Start: Apr 2017Est. completion: May 201817 patients
Phase 2Terminated

Vedolizumab Subcutaneous (SC) Versus Intravenous (IV) in Ulcerative Colitis or Crohn's Disease

Start: Apr 2014Est. completion: Dec 20150
Phase 2Withdrawn
NCT04995653Seres TherapeuticsVancomycin Pre-Treatment

A Multiple Dose Study to Evaluate Safety, Tolerability, PK, and Efficacy of SER-155 in Adults Undergoing HSCT

Start: Nov 2021Est. completion: Jul 202460 patients
Phase 1Completed

A Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Autoinjector (PFS+AI) in Healthy Participants

Start: Mar 2018Est. completion: Nov 2018204 patients
Phase 1Completed

A Study to Determine the Pharmacokinetics (PK) of Single Intravenous (IV) Dose of Vedolizumab 300 Milligram (mg) in Healthy Adult Chinese Participants

Start: Mar 2018Est. completion: Sep 201816 patients
Phase 1Completed

A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Autoinjector (PFS+AI) in Healthy Participants

Start: Feb 2018Est. completion: Aug 201824 patients
Phase 1Completed

A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Needle Safety Device (PFS+NSD) in Healthy Participants

Start: Feb 2018Est. completion: Sep 2018102 patients
Phase 1Completed

Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma

Start: Jun 2016Est. completion: May 201822 patients
Phase 1Terminated

Dose Finding Study of Vedolizumab for GvHD in Participants Undergoing Allogeneic HSCT

Start: Jun 2016Est. completion: Jul 201824 patients
Phase 1Completed

Bioavailability and Pharmacokinetics of Vedolizumab in Healthy Participants Following Single Subcutaneous Administration

Start: Jun 2014Est. completion: Jan 201548 patients
Phase 1Completed

Expanded Access to Vedolizumab for Children and Teenagers With Ulcerative Colitis or Crohn's Disease in the USA

N/AAvailable

Evaluating the Shift From Intravenous to Subcutaneous Vedolizumab for Inflammatory Bowel Disease

Start: Oct 2025Est. completion: Mar 2026120 patients
N/AActive Not Recruiting

CurQD as Add-On Therapy in Vedolizumab-Treated Ulcerative Colitis Patients: Retrospective Cohort Study

Start: Sep 2025Est. completion: Aug 2026400 patients
N/AActive Not Recruiting

A Study on How Vedolizumab is Given and the Outcomes for Adults With Inflammatory Bowel Disease (VARIETY-Belgium)

Start: Dec 2021Est. completion: Jun 2024185 patients
N/ACompleted

A Study of Vedolizumab in Adults in Real-World Practice

Start: Oct 2021Est. completion: Jul 2024500 patients
N/ACompleted

A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in Real-World Practice

Start: Aug 2021Est. completion: Jun 202499 patients
N/ACompleted

A Study of Vedolizumab and Biologic Agents in Participants With Inflammatory Bowel Disease (IBD)

Start: May 2021Est. completion: Dec 2022423 patients
N/ACompleted

Ulcerative Colitis - Vedolizumab- With/Without Prior Exposure to Anti-TNF(Tumor Necrosis Factor)Therapy

Start: Oct 2020Est. completion: Dec 20201 patients
N/ATerminated

Efficacy of Vedolizumab in Crohn's Disease Patients Naive to Biological Therapy

Start: Aug 2020Est. completion: Apr 2021100 patients
N/AUnknown

A Study of Kynteles Injection (Vedolizumab) in Adults With Moderate to Severe Ulcerative Colitis or Crohn's Disease or Chronic Pouchitis

Start: Jun 2020Est. completion: Jun 2025688 patients
N/ACompleted

Specified Drug-Use Survey on Vedolizumab for IV Infusion 300 mg [Crohn's Disease]

Start: Jul 2019Est. completion: Jun 2026335 patients
N/AActive Not Recruiting

Special Drug-Use Surveillance Study on Vedolizumab for IV Infusion 300 mg [Ulcerative Colitis]

Start: Feb 2019Est. completion: Feb 20251,110 patients
N/ACompleted

Humor Therapy and Distress After Allogeneic Stem Cell Transplantation

Start: May 2018Est. completion: Sep 2019126 patients
N/AUnknown

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

8 actively recruiting trials targeting 10,503 patients
3 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.