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Advanced Malignancies

35
Pipeline Programs
21
Companies
50
Clinical Trials
9 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
23
11
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
457%
Monoclonal Antibody
343%
+ 39 programs with unclassified modality

Competitive Landscape

21 companies ranked by most advanced pipeline stage

Incyte
IncyteDE - Wilmington
9 programs
3
5
1
PemigatinibPhase 2Small Molecule1 trial
INCAGN01876Phase 1/21 trial
INCAGN01876Phase 1/21 trial
INCAGN01876Phase 1/21 trial
INCAGN01949Phase 1/21 trial
+4 more programs
Active Trials
NCT05577182Completed46Est. Oct 2025
NCT04831944Completed21Est. Mar 2022
NCT04831996Completed48Est. Jul 2022
+6 more trials
Sandoz
SandozAustria - Kundl
8 programs
7
1
MBG453Phase 1/2
PDR001Phase 1
PatupilonePhase 1
PatupilonePhase 1
PatupilonePhase 1
+3 more programs
Astellas
AstellasChina - Shenyang
2 programs
1
1
ASP7517Phase 1/21 trial
ASP3026Phase 11 trial
Active Trials
NCT01284192Completed46Est. Mar 2016
NCT04837196Completed24Est. Jun 2024
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD7648Phase 1/21 trial
Active Trials
NCT03907969Completed30Est. Dec 2022
MSD
MSDIreland - Ballydine
1 program
1
BI-1808Phase 1/2
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
BI-1808Phase 1/2
Pfizer
PfizerNEW YORK, NY
1 program
1
PF-06801591Phase 1/21 trial
Active Trials
NCT04181788Completed155Est. May 2026
Innovent Biologics
Innovent BiologicsChina - Jiangsu
8 programs
8
IBI110Phase 11 trial
IBI188Phase 11 trial
IBI188Phase 11 trial
IBI322Phase 11 trial
IBI323Phase 11 trial
+3 more programs
Active Trials
NCT04085185Unknown268Est. Jun 2024
NCT03717103Completed49Est. Feb 2022
NCT03763149Completed20Est. Mar 2021
+5 more trials
Chia Tai TianQing Pharmaceutical Group
2 programs
1
TQB6426 for InjectionPhase 11 trial
TQB3455PHASE_11 trial
Active Trials
NCT04340427Unknown50Est. Dec 2021
NCT07730190Recruiting151Est. May 2028
Ono Pharmaceutical
Ono PharmaceuticalJapan - Osaka
1 program
1
CabiralizumabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT03158272Completed19Est. Oct 2019
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
IBI363 combined with BevacizumabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT06717880Recruiting260Est. Jul 2026
TopAlliance Biosciences
1 program
1
Part APhase 11 trial
Active Trials
NCT03474640Completed184Est. Jul 2022
Novartis
NovartisBASEL, Switzerland
2 programs
PDR001PHASE_15 trials
PatupilonePHASE_15 trials
Active Trials
NCT04237649Terminated77Est. Sep 2023
NCT03982134Withdrawn0Est. May 2022
NCT03891953Active Not Recruiting98Est. Oct 2026
+7 more trials
Elevar Therapeutics
Elevar TherapeuticsKorea - Seoul
1 program
ApatinibPHASE_1Small Molecule1 trial
Active Trials
NCT03407976Terminated5Est. Jul 2020
Regeneron
RegeneronTARRYTOWN, NY
1 program
REGN2810PHASE_11 trial
Active Trials
NCT02520245Withdrawn0Est. Nov 2023
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
WX-UK1 in combination with CapecitabinePHASE_11 trial
Active Trials
NCT00083525Completed33
Parexel
ParexelMA - Boston
1 program
AZD7648PHASE_1_2
BioInvent International
1 program
BI-1808PHASE_1_21 trial
Active Trials
NCT04752826Recruiting176Est. Jan 2028
Celldex Therapeutics
1 program
CDX-1401 in combination with Resiquimod and/or Poly-ICLCPHASE_1_21 trial
Active Trials
NCT00948961Completed70Est. Feb 2014
Bristol Myers Squibb
1 program
TanespimycinPHASE_23 trials
Active Trials
NCT00546780Completed31Est. Mar 2010
NCT00514371Completed22Est. Feb 2009
NCT00779428Completed6Est. Jul 2013
BeOne Medicines
BeOne MedicinesCA - San Carlos
1 program
TislelizumabPHASE_3Monoclonal Antibody5 trials
Active Trials
NCT07715396Not Yet Recruiting230Est. Oct 2031
NCT07746141Recruiting100Est. Sep 2028
NCT07733180Not Yet Recruiting30Est. Feb 2028
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
BeOne MedicinesTislelizumab
BeOne MedicinesTislelizumab
BeOne MedicinesTislelizumab
BeOne MedicinesTislelizumab
Bristol Myers SquibbTanespimycin
NovartisPatupilone
Bristol Myers SquibbTanespimycin
BeOne MedicinesTislelizumab
BeOne MedicinesTislelizumab
BeOne MedicinesTislelizumab
BeOne MedicinesTislelizumab
BeOne MedicinesTislelizumab
IncytePemigatinib
NovartisPDR001
NovartisPDR001

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 7,758 patients across 50 trials

Addition of Platinum-based Chemotherapy to Tislelizumab in PD-L1high Metastatic Non-small Cell Lung Cancer With a High Tumor Burden

Start: Oct 2026Est. completion: Oct 2031230 patients
Phase 3Not Yet Recruiting

A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer

Start: May 2021Est. completion: Mar 2026669 patients
Phase 3Terminated

Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies

Start: Dec 2019Est. completion: May 2026404 patients
Phase 3Completed

A Study to Investigate Tislelizumab (BGB-A317) Versus Placebo in Combination With Concurrent Chemoradiotherapy in Participants With Localized Esophageal Squamous Cell Carcinoma

Start: Jun 2019Est. completion: Mar 2025370 patients
Phase 3Completed

A Study of Tanespimycin (KOS-953) in Patients With Multiple Myeloma in First Relapse

Start: Feb 2008Est. completion: Mar 201031 patients
Phase 3Completed

Patupilone Versus Doxorubicin in Patients With Ovarian, Primary Fallopian, or Peritoneal Cancer

Start: Nov 2005829 patients
Phase 3Completed

A Study of Tanespimycin (KOS-953) in Patients With Relapsed-refractory Multiple Myeloma

Start: Aug 2007Est. completion: Feb 200922 patients
Phase 2/3Completed

A Study Investigating Alternate Schedules of Tislelizumab Plus Chemotherapy in Japanese Patients With First-line Advanced ESCC

Start: Aug 2026Est. completion: Feb 202830 patients
Phase 2Not Yet Recruiting

A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States

Start: Apr 2026Est. completion: Dec 203130 patients
Phase 2Recruiting

Tislelizumab in People With Colorectal Cancer

Start: Jul 2024Est. completion: Jul 202840 patients
Phase 2Recruiting

Tislelizumab and Metronomic Capecitabine as Maintenance in High-risk Locoregionally-advanced Nasopharyngeal Carcinoma

Start: Jul 2024Est. completion: Oct 202953 patients
Phase 2Recruiting

A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma

Start: Aug 2023Est. completion: Jul 2026160 patients
Phase 2Completed

The Purpose of the Study is to Continue to Provide Pemigatinib to Patients With Advanced Malignancies.

Start: Jul 2021Est. completion: Apr 202410 patients
Phase 2Terminated

Dabrafenib + Trametinib + PDR001 In Colorectal Cancer

Start: Oct 2018Est. completion: Dec 202225 patients
Phase 2Unknown

PDR001 Plus LAG525 for Patients With Advanced Solid and Hematologic Malignancies

Start: Jan 2018Est. completion: Sep 202076 patients
Phase 2Completed

A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma

Start: Aug 2017Est. completion: Feb 2023315 patients
Phase 2Terminated

Study of Efficacy and Safety of PDR001 in Patients With Advanced or Metastatic, Well-differentiated, Non-functional Neuroendocrine Tumors of Pancreatic, Gastrointestinal (GI), or Thoracic Origin or Poorly-differentiated Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC)

Start: Feb 2017Est. completion: May 2020116 patients
Phase 2Completed

Efficacy and Safety of Patupilone in Men (≥18 Years) With Metastatic Hormone Refractory Prostate Cancer

Start: Sep 2006Est. completion: Sep 2012185 patients
Phase 2Completed

Clinical Trial of Continuing Treatment for Patients Who Have Participated on a Prior Protocol Investigating Tanespimycin

Start: Jul 2006Est. completion: Jul 20136 patients
Phase 2Completed

Patupilone Activity in Advanced/Metastatic Hepatocellular Carcinoma

Start: Jan 200625 patients
Phase 2Completed

Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer

Start: Nov 2005Est. completion: Jun 201050 patients
Phase 2Completed

A Study Investigating the Efficacy and Safety of Alcestobart (LBL-007) Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer

Start: Jan 2023Est. completion: Dec 2026113 patients
Phase 1/2Active Not Recruiting

Study of ASP7517 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors Expressing WT1 Antigen

Start: Nov 2021Est. completion: Jun 202424 patients
Phase 1/2Completed

BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

Start: Jan 2021Est. completion: Jan 2028176 patients
Phase 1/2Recruiting

Anti-HER2 Bispecific Antibody Zanidatamab (ZW25) Activity in Combination With Chemotherapy With/Without Tislelizumab

Start: Mar 2020Est. completion: Oct 202471 patients
Phase 1/2Completed

Sasanlimab (PF-06801591, PD-1 Inhibitor) in Participants With Advanced Malignancies

Start: Mar 2020Est. completion: May 2026155 patients
Phase 1/2Completed

A Clinical Trial to Evaluate AZD7648 Alone and in Combination With Other Anti-cancer Agents in Patients With Advanced Cancers.

Start: Oct 2019Est. completion: Dec 202230 patients
Phase 1/2Completed

PDR001 Plus Imatinib for Metastatic or Unresectable GIST

Start: Feb 2019Est. completion: Nov 202139 patients
Phase 1/2Completed

Study of Surzebiclimab (BGB-A425) and Alcestobart (LBL-007) in Combination With Tislelizumab in Advanced Solid Tumors

Start: Nov 2018Est. completion: Feb 2025147 patients
Phase 1/2Completed

INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies

Start: Nov 2017Est. completion: Jul 202010 patients
Phase 1/2Terminated

A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies

Start: Oct 2017Est. completion: Sep 201952 patients
Phase 1/2Completed

Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies

Start: Apr 2017Est. completion: Nov 2021145 patients
Phase 1/2Completed

A Phase 1/2, Open-Label, Dose-Escalation, Safety Study of INCAGN01949 in Subjects With Advanced or Metastatic Solid Tumors

Start: Oct 2016Est. completion: Mar 201987 patients
Phase 1/2Completed

A Study of BLZ945 Single Agent or BLZ945 in Combination With PDR001 in Advanced Solid Tumors

Start: Oct 2016Est. completion: Dec 2022192 patients
Phase 1/2Terminated

Phase Ib/II Study of MCS110 in Combination With PDR001 in Patients With Advanced Malignancies

Start: Jun 2016Est. completion: Jun 2020141 patients
Phase 1/2Completed

A Study of INCAGN01876 in Participants With Advanced or Metastatic Solid Tumors

Start: Jun 2016Est. completion: Dec 2019100 patients
Phase 1/2Completed

Phase I-Ib/II Study of MBG453 as Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies

Start: Nov 2015Est. completion: Aug 2022252 patients
Phase 1/2Terminated

Safety and Efficacy of LAG525 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies.

Start: Jun 2015Est. completion: Dec 2020490 patients
Phase 1/2Completed

FGF401 in HCC and Solid Tumors Characterized by Positive FGFR4 and KLB Expression

Start: Dec 2014Est. completion: May 2019172 patients
Phase 1/2Completed
NCT00948961Celldex TherapeuticsCDX-1401 in combination with Resiquimod and/or Poly-ICLC

A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1

Start: Sep 2009Est. completion: Feb 201470 patients
Phase 1/2Completed

A First-in-Human Study Investigating BG-85738 Alone or in Combination With Other Antitumor Agents in Patients With Advanced or Metastatic Solid Tumors With Rat Sarcoma Virus (RAS) Mutations

Start: Sep 2026Est. completion: Sep 2028100 patients
Phase 1Recruiting

A Clinical Trial of TQB6426 for Injection in Patients With Advanced Solid Tumors

Start: Aug 2026Est. completion: May 2028151 patients
Phase 1Recruiting

A Study of ELI-002 7P, With or Without Tislelizumab, in People With Pancreatic Cancer

Start: Jun 2026Est. completion: Jun 202820 patients
Phase 1Recruiting
NCT06468098Innovent BiologicsIBI363 + chemotherapy

A Study of IBI363 in Subjects With Advanced Malignancies

Start: Jun 2024Est. completion: Dec 2026556 patients
Phase 1Recruiting

Study to Evaluate the Bioavailability of Tislelizumab Via Subcutaneous Injection in First-Line Treatment of Participants With Advanced or Metastatic Non-Small Cell Lung Cancer

Start: Nov 2023Est. completion: Aug 202662 patients
Phase 1Completed

BGB-A3055 Alone and in Combination With Tislelizumab in Participants With Solid Tumors

Start: Aug 2023Est. completion: Jan 202699 patients
Phase 1Terminated
NCT06717880UNION therapeuticsIBI363 combined with Bevacizumab

A Study of IBI363 in Combination With Bevacizumab or Furuitinib in Subjects With Advanced Colorectal Cancer

Start: Jul 2023Est. completion: Jul 2026260 patients
Phase 1Recruiting
NCT05577182IncyteINCA32459-101

Study of INCA32459 a LAG-3 and PD-1 Bispecific Antibody in Participants With Select Advanced Malignancies

Start: Jan 2023Est. completion: Oct 202546 patients
Phase 1Completed

IBI397 or Combination Therapies in Patients With Advanced Malignancies

Start: Apr 2022Est. completion: Aug 20230
Phase 1Withdrawn

Study of IBI323 in Patients With Advanced Malignancies

Start: Jun 2021Est. completion: Dec 2023322 patients
Phase 1Unknown

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

9 actively recruiting trials targeting 7,758 patients
21 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.