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Advanced Malignancies

34
Pipeline Programs
21
Companies
45
Clinical Trials
5 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
22
11
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
457%
Monoclonal Antibody
343%
+ 38 programs with unclassified modality

Competitive Landscape

21 companies ranked by most advanced pipeline stage

Incyte
IncyteDE - Wilmington
9 programs
3
5
1
PemigatinibPhase 2Small Molecule1 trial
INCAGN01876Phase 1/21 trial
INCAGN01876Phase 1/21 trial
INCAGN01876Phase 1/21 trial
INCAGN01949Phase 1/21 trial
+4 more programs
Active Trials
NCT05577182Completed46Est. Oct 2025
NCT04831996Completed48Est. Jul 2022
NCT04831944Completed21Est. Mar 2022
+6 more trials
Sandoz
SandozAustria - Kundl
8 programs
7
1
MBG453Phase 1/21 trial
PDR001Phase 11 trial
PatupilonePhase 11 trial
PatupilonePhase 11 trial
PatupilonePhase 11 trial
+3 more programs
Active Trials
NCT02678260Completed18Est. Sep 2017
NCT00448396Completed17
NCT00468260Terminated12
+5 more trials
Astellas
AstellasChina - Shenyang
2 programs
1
1
ASP7517Phase 1/21 trial
ASP3026Phase 11 trial
Active Trials
NCT01284192Completed46Est. Mar 2016
NCT04837196Completed24Est. Jun 2024
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD7648Phase 1/21 trial
Active Trials
NCT03907969Completed30Est. Dec 2022
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
BI-1808Phase 1/2
MSD
MSDIreland - Ballydine
1 program
1
BI-1808Phase 1/21 trial
Active Trials
NCT04752826Recruiting176Est. Jan 2028
Pfizer
PfizerNEW YORK, NY
1 program
1
PF-06801591Phase 1/21 trial
Active Trials
NCT04181788Active Not Recruiting155Est. Jun 2026
Innovent Biologics
Innovent BiologicsChina - Jiangsu
8 programs
8
IBI110Phase 11 trial
IBI188Phase 11 trial
IBI188Phase 11 trial
IBI322Phase 11 trial
IBI323Phase 11 trial
+3 more programs
Active Trials
NCT04085185Unknown268Est. Jun 2024
NCT03717103Completed49Est. Feb 2022
NCT03763149Completed20Est. Mar 2021
+5 more trials
Ono Pharmaceutical
Ono PharmaceuticalJapan - Osaka
1 program
1
CabiralizumabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT03158272Completed19Est. Oct 2019
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
IBI363 combined with BevacizumabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT06717880Recruiting260Est. Jul 2026
TopAlliance Biosciences
1 program
1
Part APhase 11 trial
Active Trials
NCT03474640Completed184Est. Jul 2022
Novartis
NovartisBASEL, Switzerland
2 programs
PDR001PHASE_1
PatupilonePHASE_1
Elevar Therapeutics
Elevar TherapeuticsKorea - Seoul
1 program
ApatinibPHASE_1Small Molecule1 trial
Active Trials
NCT03407976Terminated5Est. Jul 2020
Regeneron
RegeneronTARRYTOWN, NY
1 program
REGN2810PHASE_11 trial
Active Trials
NCT02520245Withdrawn0Est. Nov 2023
Chia Tai TianQing Pharmaceutical Group
1 program
TQB3455PHASE_11 trial
Active Trials
NCT04340427Unknown50Est. Dec 2021
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
WX-UK1 in combination with CapecitabinePHASE_11 trial
Active Trials
NCT00083525Completed33
Parexel
ParexelMA - Boston
1 program
AZD7648PHASE_1_2
BioInvent International
1 program
BI-1808PHASE_1_2
Celldex Therapeutics
1 program
CDX-1401 in combination with Resiquimod and/or Poly-ICLCPHASE_1_21 trial
Active Trials
NCT00948961Completed70Est. Feb 2014
Bristol Myers Squibb
1 program
TanespimycinPHASE_23 trials
Active Trials
NCT00546780Completed31Est. Mar 2010
NCT00514371Completed22Est. Feb 2009
NCT00779428Completed6Est. Jul 2013
BeOne Medicines
BeOne MedicinesCA - San Carlos
1 program
TislelizumabPHASE_3Monoclonal Antibody4 trials
Active Trials
NCT07554521Not Yet Recruiting30Est. Dec 2031
NCT07510724Recruiting240Est. Jan 2033
NCT06093061Recruiting53Est. Oct 2029
+1 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
BeOne MedicinesTislelizumab
Bristol Myers SquibbTanespimycin
Bristol Myers SquibbTanespimycin
BeOne MedicinesTislelizumab
BeOne MedicinesTislelizumab
IncytePemigatinib
Bristol Myers SquibbTanespimycin
AstellasASP7517
MSDBI-1808
PfizerPF-06801591
AstraZenecaAZD7648
IncyteINCAGN01876
IncyteINCAGN01949
IncyteINCAGN01876
IncyteINCAGN01949

Showing 15 of 45 trials with date data

Clinical Trials (45)

Total enrollment: 4,078 patients across 45 trials

Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies

Start: Dec 2019Est. completion: Jul 2026404 patients
Phase 3Active Not Recruiting

A Study of Tanespimycin (KOS-953) in Patients With Multiple Myeloma in First Relapse

Start: Feb 2008Est. completion: Mar 201031 patients
Phase 3Completed

A Study of Tanespimycin (KOS-953) in Patients With Relapsed-refractory Multiple Myeloma

Start: Aug 2007Est. completion: Feb 200922 patients
Phase 2/3Completed

A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States

Start: Sep 2026Est. completion: Dec 203130 patients
Phase 2Not Yet Recruiting

Tislelizumab and Metronomic Capecitabine as Maintenance in High-risk Locoregionally-advanced Nasopharyngeal Carcinoma

Start: Jul 2024Est. completion: Oct 202953 patients
Phase 2Recruiting

The Purpose of the Study is to Continue to Provide Pemigatinib to Patients With Advanced Malignancies.

Start: Jul 2021Est. completion: Apr 202410 patients
Phase 2Terminated

Clinical Trial of Continuing Treatment for Patients Who Have Participated on a Prior Protocol Investigating Tanespimycin

Start: Jul 2006Est. completion: Jul 20136 patients
Phase 2Completed

Study of ASP7517 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors Expressing WT1 Antigen

Start: Nov 2021Est. completion: Jun 202424 patients
Phase 1/2Completed

BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

Start: Jan 2021Est. completion: Jan 2028176 patients
Phase 1/2Recruiting

Sasanlimab (PF-06801591, PD-1 Inhibitor) in Participants With Advanced Malignancies

Start: Mar 2020Est. completion: Jun 2026155 patients
Phase 1/2Active Not Recruiting

A Clinical Trial to Evaluate AZD7648 Alone and in Combination With Other Anti-cancer Agents in Patients With Advanced Cancers.

Start: Oct 2019Est. completion: Dec 202230 patients
Phase 1/2Completed

INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies

Start: Nov 2017Est. completion: Jul 202010 patients
Phase 1/2Terminated

A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies

Start: Oct 2017Est. completion: Sep 201952 patients
Phase 1/2Completed

Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies

Start: Apr 2017Est. completion: Nov 2021145 patients
Phase 1/2Completed

A Phase 1/2, Open-Label, Dose-Escalation, Safety Study of INCAGN01949 in Subjects With Advanced or Metastatic Solid Tumors

Start: Oct 2016Est. completion: Mar 201987 patients
Phase 1/2Completed

A Study of INCAGN01876 in Participants With Advanced or Metastatic Solid Tumors

Start: Jun 2016Est. completion: Dec 2019100 patients
Phase 1/2Completed

Phase I-Ib/II Study of MBG453 as Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies

Start: Nov 2015Est. completion: Aug 2022252 patients
Phase 1/2Terminated
NCT00948961Celldex TherapeuticsCDX-1401 in combination with Resiquimod and/or Poly-ICLC

A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1

Start: Sep 2009Est. completion: Feb 201470 patients
Phase 1/2Completed

A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies

Start: May 2026Est. completion: Apr 202824 patients
Phase 1Not Yet Recruiting
NCT06468098Innovent BiologicsIBI363 + chemotherapy

A Study of IBI363 in Subjects With Advanced Malignancies

Start: Jun 2024Est. completion: Dec 2026556 patients
Phase 1Recruiting
NCT06717880UNION therapeuticsIBI363 combined with Bevacizumab

A Study of IBI363 in Combination With Bevacizumab or Furuitinib in Subjects With Advanced Colorectal Cancer

Start: Jul 2023Est. completion: Jul 2026260 patients
Phase 1Recruiting
NCT05577182IncyteINCA32459-101

Study of INCA32459 a LAG-3 and PD-1 Bispecific Antibody in Participants With Select Advanced Malignancies

Start: Jan 2023Est. completion: Oct 202546 patients
Phase 1Completed

IBI397 or Combination Therapies in Patients With Advanced Malignancies

Start: Apr 2022Est. completion: Aug 20230
Phase 1Withdrawn

Study of IBI323 in Patients With Advanced Malignancies

Start: Jun 2021Est. completion: Dec 2023322 patients
Phase 1Unknown

To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Renal Function and Renal Impairment.

Start: May 2021Est. completion: Jul 202248 patients
Phase 1Completed

To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Hepatic Function and Hepatic Impairment.

Start: Mar 2021Est. completion: Mar 202221 patients
Phase 1Completed

Safety and Efficacy of IBI322 in Chinese Subjects With Advanced Malignant Tumors

Start: Jul 2020Est. completion: Aug 202394 patients
Phase 1Completed

A Study Evaluating the Safety, Tolerability, and Initial Efficacy of Recombinant Human Anti-T-cell Immunoreceptor With Ig and ITIM Domains (TIGIT) Monoclonal Antibody Injection (IBI939) in Subjects With Advanced Malignant Tumors

Start: May 2020Est. completion: May 202234 patients
Phase 1Completed

A Study of TQB3455 Tablets in Subjects With Advanced Malignancies

Start: Apr 2020Est. completion: Dec 202150 patients
Phase 1Unknown

A Study Evaluating the Safety, Tolerability, and Initial Efficacy of IBI110 in Subjects With Advanced Malignant Tumors

Start: Dec 2019Est. completion: Jun 2024268 patients
Phase 1Unknown

A Study Evaluating the Safety, Tolerability, and Initial Efficacy of Recombinant Human Anti-cluster Differentiation Antigen 47 (CD47) Monoclonal Antibody Injection (IBI188) in Patients With Advanced Malignant Tumors and Lymphomas

Start: Feb 2019Est. completion: Mar 202120 patients
Phase 1Completed

A Phase 1 Study Evaluating the Safety, Tolerability, and Initial Efficacy of IBI188 in Advanced Malignancies

Start: Jan 2019Est. completion: Feb 202249 patients
Phase 1Completed

Apatinib With Pembrolizumab in Previously Treated Advanced Malignancies

Start: Jun 2018Est. completion: Jul 20205 patients
Phase 1Terminated

Safety, Tolerability and Pharmacokinetics of an Anti-PD-1 Monoclonal Antibody in Subjects With Advanced Malignancies

Start: Feb 2018Est. completion: Jul 2022184 patients
Phase 1Completed

A Study of Cabiralzumab Given by Itself or With Nivolumab in Advanced Cancer or Cancer That Has Spread

Start: May 2017Est. completion: Oct 201919 patients
Phase 1Completed

Phase I Study of PDR001 in Patients With Advanced Malignancies.

Start: Feb 2016Est. completion: Sep 201718 patients
Phase 1Completed

Companion Study for Patients Who Completed Participation in a REGN2810 (Anti-PD-1) Clinical Study

Start: Aug 2015Est. completion: Nov 20230
Phase 1Withdrawn

Study of an Investigational Drug, ASP3026, in Patients With Advanced Malignancies (Solid Tumors and B-Cell Lymphoma)

Start: Dec 2010Est. completion: Mar 201646 patients
Phase 1Completed

The Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies

Start: May 200712 patients
Phase 1Terminated

Evaluate the Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies

Start: Mar 200717 patients
Phase 1Completed

Pharmacokinetics of Patupilone After a Single Intravenous Administration in Patients With Advance Solid Tumor Malignancies.

Start: Aug 20065 patients
Phase 1Completed
NCT00421044SandozPatupilone/EPO906

A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function

Start: May 200614 patients
Phase 1Completed
NCT00420524SandozPatupilone/EPO906

A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function

Start: Jan 200636 patients
Phase 1Completed
NCT00083525Heidelberg PharmaWX-UK1 in combination with Capecitabine

Urokinase-Plasminogen Activator (uPA) Inhibitor WX-UK1 in Combination With Capecitabine in Advanced Malignancies

Start: May 200433 patients
Phase 1Completed

Real-World Data on the Treatment of Lung Cancer Patients With the Immune-Checkpoint Inhibitor Tislelizumab

Start: Dec 2025Est. completion: Jan 2033240 patients
N/ARecruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 actively recruiting trials targeting 4,078 patients
21 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.