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Adolescent Idiopathic Scoliosis

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Pipeline Programs
11
Companies
16
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Spine BioPharma
Spine BioPharmaNY - New York
3 programs
Adolescent Idiopathic Scoliosis Outcomes Database RegistryN/A
Flexibility RadiographsN/A1 trial
Scoliosis Specific ExercisesN/A1 trial
Active Trials
NCT03296228Completed134Est. Dec 2018
NCT02807545Completed98Est. Oct 2023
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
3 programs
Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic ScoliosisN/A1 trial
Posterior Spinal FusionN/A1 trial
Return to Sport After Posterior Spinal FusionN/A1 trial
Active Trials
NCT02315729Recruiting380Est. Dec 2028
NCT02781324Completed66Est. Jan 2018
NCT03513120Completed30Est. Aug 2020
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
2 programs
Artificial Intelligence-based Models for Spine Malalignment Auto-analysisN/A1 trial
intervertebral disc releaseN/A1 trial
Active Trials
NCT06711757Completed3,015Est. Nov 2024
NCT06279468Recruiting132Est. Sep 2026
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
Green Sun Medical BraceN/A1 trial
Momentum ApplicationN/A1 trial
Active Trials
NCT04877236Withdrawn0Est. Jul 2022
NCT06825611Not Yet Recruiting100Est. Aug 2027
NuVasive
NuVasiveCA - San Diego
1 program
Adolescent Idiopathic Scoliosis Outcomes Database RegistryN/A1 trial
Active Trials
NCT01661959Unknown10,000Est. Dec 2025
Stuart Therapeutics
1 program
BraceN/A1 trial
Active Trials
NCT00448448Terminated383Est. Sep 2013
Innovation Pharmaceuticals
1 program
Ergonomic Brace vs hard braceN/A1 trial
Active Trials
NCT03617120Completed15Est. Jan 2020
Green Sun Medical
Green Sun MedicalCO - Fort Collins
1 program
Green Sun Dynamic BraceN/A1 trial
Active Trials
NCT03641469Completed36Est. May 2024
ApiFix
ApiFixIsrael - Yokneam
1 program
MID-C SystemN/A2 trials
Active Trials
NCT04684927Withdrawn0Est. Mar 2028
NCT04296903Active Not Recruiting201Est. Jun 2030
Zimmer Biomet
Zimmer BiometFL - Jacksonville
1 program
The Spinal Tethering SystemN/A1 trial
Active Trials
NCT02897453Unknown56Est. Oct 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Angeles TherapeuticsMomentum Application
UNION therapeuticsintervertebral disc release
UNION therapeuticsArtificial Intelligence-based Models for Spine Malalignment Auto-analysis
ApiFixMID-C System
ApiFixMID-C System
Angeles TherapeuticsGreen Sun Medical Brace
Innovation PharmaceuticalsErgonomic Brace vs hard brace
Green Sun MedicalGreen Sun Dynamic Brace
Colorado TherapeuticsReturn to Sport After Posterior Spinal Fusion
Colorado TherapeuticsAnalysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis
Spine BioPharmaScoliosis Specific Exercises
Zimmer BiometThe Spinal Tethering System
Colorado TherapeuticsPosterior Spinal Fusion
Spine BioPharmaFlexibility Radiographs
Stuart TherapeuticsBrace

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 14,646 patients across 16 trials

NCT06825611Angeles TherapeuticsMomentum Application

Detecting and Monitoring Scoliosis Without Radiography: Standard Radiographic Monitoring Program Versus Self-Screening with Momentum SpineTM

Start: Mar 2025Est. completion: Aug 2027100 patients
N/ANot Yet Recruiting
NCT06279468UNION therapeuticsintervertebral disc release

Clinical Effectiveness of Intervertebral Disc Release in Treating Lenke 5 Adolescent Idiopathic Scoliosis

Start: Sep 2024Est. completion: Sep 2026132 patients
N/ARecruiting
NCT06711757UNION therapeuticsArtificial Intelligence-based Models for Spine Malalignment Auto-analysis

Artificial Intelligence-based Models for Spine Malalignment Auto-analysis

Start: Jan 2022Est. completion: Nov 20243,015 patients
N/ACompleted
NCT04684927ApiFixMID-C System

PMS Evaluation of Safety and Efficacy of the MID-C System 5 Years Post-implantation in AIS

Start: Jan 2021Est. completion: Mar 20280
N/AWithdrawn
NCT04296903ApiFixMID-C System

Post-approval Registry Study to Evaluate the Continued Safety and Probable Benefit of the MID-C System for 5 Years Post-Implantation in Adolescent Idiopathic Scoliosis (AIS)

Start: May 2020Est. completion: Jun 2030201 patients
N/AActive Not Recruiting
NCT04877236Angeles TherapeuticsGreen Sun Medical Brace

Green Sun Medical Dynamic Brace

Start: Nov 2019Est. completion: Jul 20220
N/AWithdrawn
NCT03617120Innovation PharmaceuticalsErgonomic Brace vs hard brace

Ergonomic Brace Wear for Adolescent Idiopathic Scoliosis

Start: Aug 2018Est. completion: Jan 202015 patients
N/ACompleted
NCT03641469Green Sun MedicalGreen Sun Dynamic Brace

Green Sun Medical Dynamic Scoliosis Brace

Start: May 2018Est. completion: May 202436 patients
N/ACompleted
NCT03513120Colorado TherapeuticsReturn to Sport After Posterior Spinal Fusion

Return to Sport After Posterior Spinal Fusion

Start: Mar 2018Est. completion: Aug 202030 patients
N/ACompleted
NCT02315729Colorado TherapeuticsAnalysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis

Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis

Start: Nov 2016Est. completion: Dec 2028380 patients
N/ARecruiting
NCT02807545Spine BioPharmaScoliosis Specific Exercises

Scoliosis-Specific Exercises for At-Risk AIS Curves

Start: Aug 2016Est. completion: Oct 202398 patients
N/ACompleted
NCT02897453Zimmer BiometThe Spinal Tethering System

Safety and Efficacy Study of Spinal Tethering

Start: Jul 2016Est. completion: Oct 202256 patients
N/AUnknown
NCT02781324Colorado TherapeuticsPosterior Spinal Fusion

Use of Ultrasonic Bone Scalpel in Adolescent Idiopathic Scoliosis

Start: Jun 2016Est. completion: Jan 201866 patients
N/ACompleted
NCT03296228Spine BioPharmaFlexibility Radiographs

Comparison of Dynamic Radiographs in Determining Fusion Level in Adolescent Idiopathic Scoliosis Correction

Start: May 2016Est. completion: Dec 2018134 patients
N/ACompleted
NCT00448448Stuart TherapeuticsBrace

Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST)

Start: Feb 2007Est. completion: Sep 2013383 patients
N/ATerminated
NCT01661959NuVasiveAdolescent Idiopathic Scoliosis Outcomes Database Registry

Adolescent Idiopathic Scoliosis Outcomes Database Registry

Start: Jan 2005Est. completion: Dec 202510,000 patients
N/AUnknown

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 14,646 patients
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.