Skip to main content

Achalasia

2
Pipeline Programs
4
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
2 programs
1
Per oral endolumenal myotomyPhase 21 trial
Endoscopic MyotomyN/A1 trial
Active Trials
NCT01399476Completed350Est. Aug 2019
NCT01302288Unknown20
Cyclerion Therapeutics
1 program
1
OlinciguatPhase 21 trial
Active Trials
NCT02931565Terminated9Est. May 2018
Eppendorf
EppendorfGermany - Hamburg
3 programs
Endoscopic Peroral MyotomyN/A1 trial
Peroral Endoscopic MyotomyN/A1 trial
Peroral Endoscopic MyotomyN/A1 trial
Active Trials
NCT01405417Terminated70Est. Sep 2017
NCT01601678Completed240Est. May 2023
NCT01405469Completed16Est. Nov 2016
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
hot water drinking therapyN/A1 trial
Active Trials
NCT01863966Unknown100Est. Dec 2015

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Cyclerion TherapeuticsOlinciguat
Oregon TherapeuticsPer oral endolumenal myotomy
EppendorfPeroral Endoscopic Myotomy
EppendorfEndoscopic Peroral Myotomy
EppendorfPeroral Endoscopic Myotomy
Oregon TherapeuticsEndoscopic Myotomy
UNION therapeuticshot water drinking therapy

Clinical Trials (7)

Total enrollment: 805 patients across 7 trials

NCT02931565Cyclerion TherapeuticsOlinciguat

Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia

Start: Apr 2017Est. completion: May 20189 patients
Phase 2Terminated
NCT01302288Oregon TherapeuticsPer oral endolumenal myotomy

Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia

Start: Oct 201020 patients
Phase 2Unknown
NCT01601678EppendorfPeroral Endoscopic Myotomy

Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia

Start: Dec 2012Est. completion: May 2023240 patients
N/ACompleted
NCT01405417EppendorfEndoscopic Peroral Myotomy

Endoscopic Peroral Myotomy for Treatment of Achalasia

Start: Apr 2011Est. completion: Sep 201770 patients
N/ATerminated
NCT01405469EppendorfPeroral Endoscopic Myotomy

Endoscopic Peroral Myotomy for Treatment of Achalasia

Start: Nov 2010Est. completion: Nov 201616 patients
N/ACompleted
NCT01399476Oregon TherapeuticsEndoscopic Myotomy

Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia

Start: Sep 2010Est. completion: Aug 2019350 patients
N/ACompleted
NCT01863966UNION therapeuticshot water drinking therapy

Hot Water Drinking Therapy in Achalasia

Start: Mar 2010Est. completion: Dec 2015100 patients
N/AUnknown

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.