Verastem Oncology

MA - Needham

Biotechnology

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Focus: Drugs Targeting Cancer Stem Cells

Verastem Oncology is a life sciences company focused on Drugs Targeting Cancer Stem Cells.

OncologyCell Therapy

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Products & Portfolio (1)

AVMAPKI FAKZYNJA CO-PACK (COPACKAGED)

avutometinib potassium and defactinib hydrochloride

Launch

ORAL · CAPSULE, TABLET

MEK1 inhibitor. Avutometinib induces the formation of inactive RAF/MEK complexes and prevents phosphorylation of MEK1/2 by RAF. RAF and MEK proteins are regulators of the RAS/RAF/MEK/ERK (MAPK) pathway. Avutometinib inhibited MEK1/2 and ERK1/2 phosphorylation and proliferation of tumor cell lines harboring KRAS mutations. Treatment of cancer cells with avutometinib increased the level of phosphorylated focal adhesion kinase (FAK). Defactinib Defactinib is an inhibitor of FAK and proline-rich tyrosine kinase-2 (Pyk2), the two members of the FAK family of nonreceptor tyrosine kinases. Defactinib inhibited FAK autophosphorylation in cancer cells in vitro and in mouse xenograft models. Avutometinib in combination with defactinib enhanced inhibition of cell proliferation in vitro and anti-tumor activity in mouse tumor models including LGSOC.

ovarian cancer

2025

Open Jobs (15)

Interview Prep Quick Facts

Portfolio: 1 approved product

Top TAs: Oncology

Open Roles: 15 active jobs

Portfolio Health

Launch1 (100%)

1 total products

Therapeutic Area Focus

Oncology

1 marketed

Marketed

Pipeline

Hiring Trend

Actively Hiring

Open Roles

Added

-0

Filled/Removed

Based on last 4 crawl cycles

Verastem Oncology

Products & Portfolio (1)

Open Jobs (15)

Strategic Account Director, Market Access

Executive / Senior Medical Director, Clinical Development

Manager, Development and Commercial Applications

In-House Contracts Attorney

Drug Safety Specialist

Associate Director/Director Drug Substance Development and Manufacturing, CMC

Oncology Account Manager, Texas-East

Senior Director, Regulatory Affairs

Human Resources Specialist (Part-Time)

Oncology Account Manager, South West

TMF Document Specialist

Medical Science Liaison/ Senior Medical Science Liaison (Pacific North West)

Oncology Account Manager, Gulf Coast

Senior PV Operations Specialist

Medical Science Liaison / Senior Medical Science Liaison (Midwest)

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