PleoPharma
PA - Phoenixville
PharmaceuticalFocus: Cannabis Withdrawal Therapy
PleoPharma is a life sciences company focused on Cannabis Withdrawal Therapy.
Immunology
Funding Stage
PUBLIC
Open Jobs
0
Products & Portfolio (2)
DOVONEX
calcipotriene
LOE Approaching
TOPICAL · SOLUTION
CLINICAL PHARMACOLOGY In humans, the natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D 3 (cholecalciferol) in the skin. Calcipotriene is a synthetic analog of vitamin D 3 . Clinical studies with radiolabelled calcipotriene ointment indicate that approximately 6% (± 3%, SD) of the applied dose of calcipotriene is absorbed systemically when the ointment is applied topically to psoriasis plaques, or 5% (± 2.6%, SD) when applied to normal skin, and much of the absorbed active is converted to inactive metabolites within 24 hours of application. Systemic absorption of the cream has not been studied. Vitamin D and its metabolites are transported in the blood, bound to specific plasma proteins. The active form of the vitamin, 1,25-dihydroxy vitamin D 3 (calcitriol), is known to be recycled via the liver and excreted in the bile. Calcipotriene metabolism following systemic uptake is rapid, and occurs via a similar pathway to the natural hormone.
plaque psoriasispsoriasis
1997
30
PINDAC
pinacidil
LOE Approaching
ORAL · CAPSULE, EXTENDED RELEASE
1989
30
Open Jobs (0)
No open positions listed yet. Check their careers page directly.
Interview Prep Quick Facts
Founded: 2019
Portfolio: 2 approved products
Top TAs: Immunology
Portfolio Health
LOE Approaching2 (100%)
2 total products