NorthStar Medical Technologies
WI - Beloit
Biotechnology3 H-1B visas (FY2023)Focus: Medical Radioisotopes
NorthStar Medical Technologies is a life sciences company focused on Medical Radioisotopes.
NeurologyCardiovascularOncology
Open Jobs
0
Products & Portfolio (6)
7 discontinued products not shown
BACLOFEN
baclofen
Post-LOE
ORAL · TABLET
CLINICAL PHARMACOLOGY The precise mechanism of action of baclofen is not fully known. Baclofen is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Although baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.
the treatment of skeletal muscle spasm resulting from rheumatic disordersmultiple sclerosisParkinson's disease
2009
30
BACLOFEN
baclofen
Post-LOE
ORAL · TABLET
GABA A Agonists
the treatment of skeletal muscle spasm resulting from rheumatic disordersmultiple sclerosisParkinson's disease
2009
30
GEMFIBROZIL
gemfibrozil
Post-LOE
ORAL · TABLET
Peroxisome Proliferator-activated Receptor alpha Agonists
2010
30
HYDROXYZINE HYDROCHLORIDE
hydroxyzine hydrochloride
Post-LOE
ORAL · TABLET
2008
30
HYDROXYZINE HYDROCHLORIDE
hydroxyzine hydrochloride
Post-LOE
ORAL · TABLET
CLINICAL PHARMACOLOGY HydrOXYzine hydrochloride is unrelated chemically to the phenothiazines, reserpine, meprobamate or the benzodiazepines. HydrOXYzine is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the central nervous system. Primary skeletal muscle relaxation has been demonstrated experimentally. Bronchodilator activity, and antihistaminic and analgesic effects have been demonstrated experimentally and confirmed clinically. An antiemetic effect, both by the apomorphine test and the veriloid test, has been demonstrated. Pharmacological and clinical studies indicate that hydrOXYzine in therapeutic dosage does not increase gastric secretion or acidity and in most cases has mild antisecretory activity. HydrOXYzine is rapidly absorbed from the gastrointestinal tract and hydrOXYzine's clinical effects are usually noted within 15 to 30 minutes after oral administration.
anxiety
2008
30
HYDROXYZINE HYDROCHLORIDE
hydroxyzine hydrochloride
Post-LOE
ORAL · TABLET
2008
30
Open Jobs (0)
No open positions listed yet. Check their careers page directly.
Interview Prep Quick Facts
Portfolio: 13 approved products
Top TAs: Neurology, Cardiovascular, Oncology
H-1B (2023): 3 approvals
Portfolio Health
Peak1 (8%)
Post-LOE12 (92%)
13 total products
Visa Sponsorship
Sponsors Work Visas
H-1B Petitions (FY2023)
3
Approved
0
Denied
100%
Rate
Source: USCIS H-1B Employer Data Hub