Fennec Pharmaceuticals

NC - Durham

Pharmaceutical

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Focus: Small Molecules, Cyclic Peptides

Fennec Pharmaceuticals is a life sciences company focused on Small Molecules, Cyclic Peptides.

Neurology

Open Jobs

2

Products & Portfolio (1)

sodium thiosulfate

INTRAVENOUS · SOLUTION

Cisplatin-induced ototoxicity is caused by irreversible damage to hair cells in the cochlea hypothesized to be due to a combination of reactive oxygen species (ROS) production and direct alkylation of DNA leading to cell death. Sodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. In addition, sodium thiosulfate can enter cells through the sodium sulfate cotransporter 2 and cause intracellular effects such as the increase in antioxidant glutathione levels and inhibition of intracellular oxidative stress. Both activities may contribute to the ability of sodium thiosulfate to reduce the risk of ototoxicity. Concurrent incubation of sodium thiosulfate with cisplatin decreased the in vitro cytotoxicity of cisplatin to tumor cells; delaying the addition of sodium thiosulfate to these cultures prevented the protective effect.

ototoxicity associated with cisplatin in pediatric patients 1 month of ageolder with localizednon-metastatic solid tumors

Open Jobs (2)

Key Account Director – West Coast

West Coast, USA

Market Access-Oncology

$200K - $260K/yr

Territory Manager – New York

Commercial Sales

$95K - $125K/yr

Interview Prep Quick Facts

Portfolio: 1 approved product

Top TAs: Oncology

Open Roles: 2 active jobs

Portfolio Health

Peak1 (100%)

1 total products

Therapeutic Area Focus

1 marketed

Marketed

Pipeline